Shaanxi's Chen Yanyu was an assist shy of a triple-double with 21 points, 12 rebounds and nine assists. Li weighed in with 19 points.
Also missing will be injured left-back Nilson Loyola and influential winger Edison Flores, whose club DC United refused to release him because of a mandatory 14-day self-quarantine for those returning to the United States capital from abroad. In addition, forward Jefferson Farfan is in doubt for the matches after re-injuring his troublesome left knee.
Tuchel's side have been drawn with Manchester United, Istanbul Basaksehir and RB Leipzig in this season's UEFA Champions League group stage.
Freiburg staged a well-positioned defense from the kickoff and was able to keep Lucien Favre's men on the distance in the opening stage.
The former NHL player Marko Dano, who returned home to play ice hockey in Slovakia, led the scoring department with two goals and one assist and guided his teammates to a convincing 5-2 victory. Enditem
It was not the only stunning result of the weekend. Tottenham inflicted a humiliating 6-1 defeat on Manchester United at Old Trafford as the home side's defense imploded in a disastrous performance that Spurs exploited to the full.
Khachanov won the pair's previous encounter in Paris - at 2018 Paris Masters, when the Russian claimed a straight-set win in the final to clinch the biggest title of his career until now.
Universidad Catolica midfielder Jose Carabali also earned his first national call-up for the matches in Buenos Aires on October 8 and Quito five days later.
Jose Bordalas' men now travel to play Real Sociedad - one of the most attractive sides in La Liga, but who have struggled for form at home since the return of football in June.
Argentina will face Ecuador in Buenos Aires on Thursday and Bolivia in La Paz five days later.
James has been in sparkling form since joining Everton from Real Madrid on a free transfer last month, scoring three goals in his first four Premier League outings.